Sartorius Celsius S3 Mode D'emploi page 5

_Manual_Benchtop_Freeze_Thaw_System_S--6004-t210308_85034-538-54.indb 5 _Manual_Benchtop_Freeze_Thaw_System_S--6004-t210308_85034-538-54.indb 5
1 Introduction
Sartorius offers scalable freeze-thaw solutions using patented technologies
for the handling, storage, and transport of biopharmaceuticals, including
tools for process development, pilot scale operation, and commercial scale
production. The benchtop system configurations are designed to reproduce
the controlled freeze-thaw processes that occur in the large–volume,
production-scale Celsius and Cryovessel processes. Cryovessel is a
®
stainless steel product line, and Celsius
systems use the Cryopilot A chiller and Cryomixer Jr. shaker.
1.1 Cryovessel
The bench-scale system for Cryovessel is called the Cryowedge. The
Cryowedge module duplicates a small section of the Cryovessel by
matching the heat exchange surface geometry, freeze path length, and
material of construction.
Product volume requirements for feasibility studies can be further reduced
by the use of the Cryocassette. These are 30 mL and 100 mL stainless steel
containers that can be fitted into the Cryowedge in polymeric sleeves.
1.2 Celsius
®
The bench-scale system for Celsius
for Scale-down, and Stability Studies. The S
FT100 Freeze-Thaw Modules by matching the freeze path length.
The Celsius S Benchtop System produces similar freeze-thaw times
® 3
allowing for scalable freeze-thaw tests and stability studies.
1.3 References
Refer to the following documents for more information about the
components of your benchtop freeze-thaw system:
— Huber Unistat 705 Operating Instructions
— Huber Unistat 705 Electrical Schematics
— Dow Syltherm HF Product Information
— Dow Syltherm HF Material Safety Data Sheet (MSDS)
— DuPont Suva 507 Material Safety Data Sheet (MSDS)
— DuPont Suva 23 Material Safety Data Sheet (MSDS)
Operating Instructions Celsius
Introduction
is a single-use product line. Both
®
is called the S Module; S stands
® 3 3
Module models the FT16 and
3
S Benchtop System
® 3
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